scE2G: linking enhancers to their target genes from single-cell data

Introducing scE2G: a new model to link enhancers to their target genes using single-cell data.

Connecting a regulatory element to the gene it actually controls is one of the central problems in genome biology — and doing it from single-cell measurements means we can, in principle, build enhancer maps in hundreds of cell types across the human body, rather than in a handful of well-studied cell lines. That’s the promise we’re most excited about.

This was a wonderful collaboration with Robin Andersson, Wei-Lin Qiu, Maya Sheth, and colleagues.

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Read the preprint on bioRxiv · Code on GitHub · Adapted from the original announcement on Bluesky.