Blog
Notes from the lab.
Plain-language write-ups of our papers and tools, reformatted from Jesse's threads. Follow along for new work as it comes out.
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Why guinea pigs grow natural bypass arteries — and how we might too
An in vivo Perturb-seq screen, guided by the differences between species, uncovers the pathways that build protective collateral arteries.
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What we learn by CRISPR'ing a random set of regulatory elements
An unbiased CRISPRi survey of ~1,000 randomly chosen accessible sites — and a new toolkit (DC-TAP-seq) for measuring enhancer effects on gene expression.
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The E2G Portal: enhancer–gene predictions across 1,600+ cell types
A major milestone in mapping enhancers and interpreting variants — browse our enhancer-gene predictions across more than 1,600 cell types and tissues at e2g.stanford.edu.
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Rewriting regulatory DNA to dissect and reprogram gene expression
Variant-EFFECTS uses high-throughput prime editing, flow sorting, and sequencing to precisely measure how noncoding variants change gene expression — now in Cell.
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A regulatory map of the human fetal heart, and the roots of congenital heart defects
A multiomic atlas of the human fetal heart plus human genetics reveals new cell types, genes, and pathways that shape heart development and disease.
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scE2G: linking enhancers to their target genes from single-cell data
A new model that uses single-cell data to connect enhancers to the genes they regulate — a step toward building enhancer maps across hundreds of human cell types.